Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 11, Pages 757-766Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri2644
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The seminal studies characterizing T follicular helper (T-FH) cells described a non-polarized CD4(+) T cell population with a unique ability to home to B cell follicles and to induce antibody production by B cells. In the past few years, the study of T-FH cells has enjoyed a renaissance and there has been a surge of research activity aimed at understanding the function and differentiation of these important cells. This Review focuses on the current progress in T-FH cell biology and the important questions that remain unanswered. Particular attention is paid to recent studies that support the idea that T-FH cells are a separate T cell lineage and those that probe the relationship of T-FH cells to other T helper cell subsets.
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