Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 11, Pages 767-777Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2656
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Funding
- US National Institutes of Health. [AI064930, AO076505, AR058481]
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Bone marrow-derived B cells make an important cell fate choice to develop into either follicular B cells or marginal zone B cells in the spleen, which depends on signalling through the B cell receptor, Notch2, the receptor for B cell-activating factor and the canonical nuclear factor-kappa B pathway, as well as signals involved in the migration and anatomical retention of marginal zone B cells. Recent information discussed in this Review reconciles some of the controversies regarding the role of the B cell receptor in this cell fate decision and a clearer picture has also emerged regarding the anatomical location of ligands for Notch2 in the spleen. This cell fate decision could provide mechanistic insights that are relevant to other commitment events in lymphocytes.
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