Journal
AEROSOL SCIENCE AND TECHNOLOGY
Volume 43, Issue 10, Pages 970-977Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/02786820903082029
Keywords
-
Categories
Funding
- TSE Systems, Inc., Chesterfield, MO 63005, USA
Ask authors/readers for more resources
The use of respiratory tract dosimetry predictions to estimate the desired aerosol exposure concentration required for a specific target deposited dose in animal inhalation studies has been hindered by: (1) a lack of species/strain specific quantitative respiratory tract anatomy; and (2) verification by comparison of calculated and experimentally measured deposited doses. Using recent literature on tracheobronchial and pulmonary respiratory tract anatomy, dosimetry predictions for the Balb/c mouse were compared with deposited doses for 0.5, 1.0, and 2.0 micrometer diameter aerosols in a newly available nose-only exposure system. Spatial and temporal aerosol port to port uniformity of this nose-only exposure system was within +/- 10% of the mean. Dosimetry predictions were in agreement with the measured mean deposited doses for the aerosols tested.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available