Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 29, Issue 2, Pages 919-925Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2015.10.014
Keywords
Myeloid-derived suppressor cells (MDSCs); S100A8/A9; Tumor; Autoimmune diseases (AIDs)
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Funding
- Shantou University Medical College (SUMC) Clinical Research Enhancement Initiative Fund
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that constitute an important component of immune regulatory system. Two calcium-binding proteins S100A8 and S100A9 act as important mediators in acute and chronic inflammation. In recent years, many researchers have found that MDSCs and S100A8/A9 operated with one another through a positive feedback loop to promote tumor development and metastasis. However, the correlation between MDSCs and S100A8/A9 in autoimmune diseases (AIDs) remains unknown. In this review, we discussed the co-operation of MDSCs and S100A8/A9 in tumor environment, and also, the role of these two components in AIDs. (C) 2015 Elsevier B.V. All rights reserved.
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