Journal
INTERNATIONAL IMMUNOLOGY
Volume 28, Issue 2, Pages 55-64Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxv048
Keywords
acute rejection; liver transplantation; receiver operating characteristic curves; Treg
Categories
Funding
- Instituto de Salud Carlos III
- Fondo de Investigaciones Sanitarias - Instituto de Salud Carlos III (ISCIII) [PI080300, PI080157, PI080160, PI080446, PI1102686, PI1109900, PI1501370]
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Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation with the presence of AR. The percentage of central memory (cm) Treg cells (CD4(+)CD25(high)CD45RO(+)CD62L(+)) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year post-transplantation. The same validation standard operating procedures were used in all participating centers. Fifteen patients developed AR (23.4%). Hepatitis C virus recurrence was observed in 16 recipients, who displayed low peripheral blood cmTreg levels compared with patients who did not. A steady increase of cmTregs was observed during the first month after transplantation with statistically significant differences between AR and non-AR patients. The high frequency of memory Treg cells allowed us to monitor rejection episodes during the first month post-transplantation. On the basis of these data, we developed a prediction model for assessing risk of AR that can provide clinicians with useful information for managing patients individually and customizing immunosuppressive therapies.
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