Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 12, Pages 858-870Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2670
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Funding
- US National Institutes of Health [RO1DK063158, RO1DK58727, P30DK42086]
- Research Council of Norway
- European Commission
- South- Eastern Norway Regional Health Authority
- Juvenile Diabetes Research Foundation
- Norwegian Foundation for Health and Rehabilitation
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Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation-induced either by infectious agents or by gluten-is crucial for activating T cells and eliciting their tissue-destructive effector functions.
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