Journal
ADVANCES IN PHYSIOLOGY EDUCATION
Volume 38, Issue 2, Pages 135-139Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/advan.00094.2013
Keywords
immunoneurology; inflammation; vagus nerve; homeostasis; immunity
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Funding
- Svenska Lakaresallskapet
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Neural reflexes support homeostasis by modulating the function of organ systems. Recent advances in neuroscience and immunology have revealed that neural reflexes also regulate the immune system. Activation of the vagus nerve modulates leukocyte cytokine production and alleviates experimental shock and autoimmune disease, and recent data have suggested that vagus nerve stimulation can improve symptoms in human rheumatoid arthritis. These discoveries have generated an increased interest in bioelectronic medicine, i.e., therapeutic delivery of electrical impulses that activate nerves to regulate immune system function. Here, we discuss the physiology and potential therapeutic implications of neural immune control.
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