Journal
ADVANCES IN PHYSIOLOGY EDUCATION
Volume 37, Issue 4, Pages 284-291Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/advan.00058.2013
Keywords
pattern recognition receptors; Toll-like receptors; pathogen-associated molecular patterns; damage-associated molecular patterns; chemokines; antigen presentation; vaccines
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Funding
- NIGMS NIH HHS [R01 GM102589] Funding Source: Medline
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Infection by pathogenic microbes initiates a set of complex interactions between the pathogen and the host mediated by pattern recognition receptors. Innate immune responses play direct roles in host defense during the early stages of infection, and they also exert a profound influence on the generation of the adaptive immune responses that ensue. An improved understanding of the pattern recognition receptors that mediate innate responses and their downstream effects after receptor ligation has the potential to lead to new ways to improve vaccines and prevent autoimmunity. This review focuses on the control of innate immune activation and the role that innate immune receptors play in helping to maintain tissue homeostasis.
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