Journal
PHYSICAL BIOLOGY
Volume 6, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1478-3975/6/4/046017
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Funding
- BSF [2006285]
- Direct For Mathematical & Physical Scien
- Division Of Astronomical Sciences [2006285] Funding Source: National Science Foundation
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The role of the coupling between the shape of membrane-bound filaments and the membrane is demonstrated for the dynamics of FtsZ rings on cylindrical membranes. Filaments with an arc-like spontaneous curvature, and a possible added active contractile force, are shown to spontaneously condense into tight rings, associated with a local inward deformation of the membrane. The long-range membrane-mediated interactions are attractive at short ring-ring separations, inducing further coarsening dynamics, whereby smaller rings merge to form larger and fewer rings that deform the membrane more strongly. At the same time, these interactions induce a potential barrier that can suppress further ring coalescence at a separation of about seven times the cylinder radius. These results of the model are in very good agreement with recent in-vitro experiments on the dynamics of FtsZ filaments in cylindrical liposomes. These results emphasize the important role of long-range membrane-mediated interactions in the organization of cytoskeletal elements at the membrane.
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