Journal
ADVANCES IN COLLOID AND INTERFACE SCIENCE
Volume 205, Issue -, Pages 134-155Publisher
ELSEVIER
DOI: 10.1016/j.cis.2013.10.020
Keywords
Gemini surfactants; Natural amino acid-based surfactants; Toxicity; Aggregation; Delivery systems
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Funding
- Ministerio de Economia y Competitividad [CTQ2009-14151-C02-02, CTQ2010-14897]
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In this review, we report the most important contributions in the structure, synthesis, physicochemical (surface adsorption, aggregation and phase behaviour) and biological properties (toxicity, antimicrobial activity and biodegradation) of Gemini natural amino acid-based surfactants, and some potential applications, with an emphasis on the use of these surfactants as non-viral delivery system agents. Gemini surfactants derived from basic (Arg, Lys), neutral (Ser, Ala, Sar), acid (Asp) and sulphur containing amino acids (Cys) as polar head groups, and Geminis with amino acids/peptides in the spacer chain are reviewed. (C) 2013 Elsevier B.V. All rights reserved.
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