Journal
ADVANCES IN CHRONIC KIDNEY DISEASE
Volume 21, Issue 1, Pages 56-63Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2013.06.010
Keywords
Chemotherapy; Acute kidney injury; Chronic kidney disease; Fanconi syndrome
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Chemotherapy holds tremendous potential in improving the survival of patients with cancer. However, the side effects of these drugs, including those that affect the kidney, can adversely affect patient outcomes. Prompt recognition of these adverse kidney effects allows early intervention that can minimize or prevent patient morbidity. In this review, we examine the nephrotoxic potential of chemotherapy drugs. In concentrating on tubulointerstitial injury, we will review common agents that result in acute kidney injury due to acute tubular necrosis, tubulopathies, crystal nephropathy, acute interstitial nephritis, and chronic interstitial nephritis, and we will present preventive and management strategies. (C) 2014 by the National Kidney Foundation, Inc. All rights reserved.
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