Journal
ADVANCES IN CHRONIC KIDNEY DISEASE
Volume 20, Issue 6, Pages 500-507Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2013.06.003
Keywords
Nanoparticles; Kidney; Glomerulus; Drug targeting; Glomerulonephritis
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Funding
- Materials Research Science and Engineering Centers program of the National Science Foundation [DMR-0520565]
- National Cancer Institute [CA151819]
- Sanofi-Aventis
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Nanoparticles are an enabling technology for the creation of tissue-/cell-specific therapeutics that have been investigated extensively as targeted therapeutics for cancer. The kidney, specifically the glomerulus, is another accessible site for nanoparticle delivery that has been relatively overlooked as a target organ. Given the medical need for the development of more potent, kidney-targeted therapies, the use of nanoparticle-based therapeutics may be one such solution to this problem. Here, we review the literature on nanoparticle targeting of the glomerulus. Specifically, we provide a broad overview of nanoparticle-based therapeutics and how the unique structural characteristics of the glomerulus allow for selective, nanoparticle targeting of this area of the kidney. We then summarize literature examples of nanoparticle delivery to the glomerulus and elaborate on the appropriate nanoparticle design criteria for glomerular targeting. Finally, we discuss the behavior of nanoparticles in animal models of diseased glomeruli and review examples of nanoparticle therapeutic approaches that have shown promise in animal models of glomerulonephritic disease. (C) 2013 by the National Kidney Foundation, Inc. All rights reserved.
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