Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 48, Pages 26400-26404Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b09820
Keywords
electrospinning; bicomponent; control release; intra-abdominal infections; antibacterial activity
Funding
- National Nature Science Foundation of China [51003110]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KJCX2-YM-H19]
Ask authors/readers for more resources
Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available