4.1 Article

Clozapine-associated neutropenia and agranulocytosis in Argentina (2007-2012)

Journal

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume 30, Issue 2, Pages 109-114

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YIC.0000000000000060

Keywords

agranulocytosis; Argentina; clozapine; leukopenia; pharmacovigilance

Funding

  1. 'Ramon Carrillo-Arturo Onativia' from Comision Nacional Salud Investiga, Ministerio de Salud y Accion Social de la Nacion, Argentina
  2. Bruce J. Anderson Foundation grant
  3. McLean Private Donors Research Fund

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The risks of severe leukopenia and agranulocytosis have varied over time and among geographical regions and cultures, with little information available on South American populations. Accordingly, we reviewed and analyzed data from a 6-year experience monitored by an Argentine national registry to which reporting of adverse events reports is required. We analyzed data for 2007-2012 from the pharmacovigilance program of the Argentine drug-regulatory agency (ANMAT) using standard bivariate and multivariate statistical methods and survival analysis. We identified 378 cases of adverse hematological events over 6 years among an average of 12 305 individuals/year treated with clozapine (308 +/- 133 mg/day) to estimate the mean annualized rates of leukopenia [0.19 (95% confidence interval [CI] 0.11-0.27)], neutropenia [0.38 (95% CI 0.34-0.43)], and agranulocytosis [0.05 (95% CI 0.02-0.08)] % per year [median latency 2 (95% CI 1.3-2.1) months]; fatalities related to agranulocytosis averaged 4.2 (95% CI 0.0-9.2) per 100 000 treated individuals/year. Factors associated significantly and independently with agranulocytosis were female sex, older age, and use of other drugs in addition to clozapine. With monitoring by international standards, recent risks of clozapine-associated agranulocytosis in Argentina were lower, but fatality rates were higher than that in other regions of the world. Risk factors include the use of multiple psychotropic drugs, female sex, and older age. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

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