Journal
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume 30, Issue 3, Pages 175-178Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YIC.0000000000000067
Keywords
dopamine transporter; generalized anxiety disorder; serotonin transporter
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Funding
- National Science Council of Taiwan [NSC 93-2314-B-006-107, NSC 95-2314-B-006-115-MY2, NSC 97-2314-B-006-006-MY3, NSC 100-2314-B-006-041-MY3]
- Atomic Energy Council of Taiwan [NSC 99-NU-E-006-003]
- Headquarters of University Advancement at the National Cheng Kung University by Ministry of Education, Taiwan, ROC [D102-35001, D103-35A09]
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Dopamine and serotonin have been indirectly found to be associated with generalized anxiety disorder (GAD). The aims of this study were to examine the availabilities of the striatal dopamine transporter (DAT) and the midbrain serotonin transporter (SERT) in patients with GAD. 12 patients with GAD and 12 sex-matched, age-matched, and smoking status-matched healthy controls were recruited. The availabilities of DAT and SERT were approximated using single-photon emission computed tomography, with [Tc-99m] TRODAT-1 and [I-123]ADAM as the ligands. There were several missing data for six participants with GAD in the ADAM study because of a lack of the radioligand at the time of the experiment. The DAT availability in the striatum was significantly lower in the patients with GAD than in the healthy controls. However, the SERT availability did not differ between the two groups. The results with respect to the striatal DAT level suggested a potential role in the pathophysiology of GAD. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
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