Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 20, Pages 10785-10794Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b01310
Keywords
silver; stainless steel; antimicrobial; osteogenic; plasma immersion ion implantation
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [81271962, 81301571, 8111704, 31370962]
- Shanghai Committee of Science and Technology, China [11DJ1400304, 12441903102, 14XD1403900]
- Shanghai Rising-Star Program [15QA1404100]
- Youth Innovation Promotion Association CAS [2015204]
- Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201206SIC]
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Prevention. of implant loosening and infection is crucial to orthopedic and dental surgeries. In this work, the surface of stainless steel (SS) was modified by silver-sourced plasma immersion ion implantation (Ag-PIII). Metallic silver nanoparticles with various diameters and distributions were fabricated on the-SS surfaces after treatment with Ag-PIII for 0.5 and 1.5 h, respectively. The osteogenic activity and antimicrobial properties of SS before and after Ag-PIII treatment were evaluated using in vitro and in vivo tests. The results demonstrated that Ag-PIII treatment not only promoted the antibacterial activity of SS but also enhanced the osteogenic differentiation of human bone marrow stromal cells.
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