Journal
ADVANCES IN ANATOMIC PATHOLOGY
Volume 15, Issue 6, Pages 332-349Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAP.0b013e31818a64af
Keywords
familial thyroid carcinoma; familial medullary thyroid carcinoma; familial papillary thyroid carcinoma; familial nonmedullary thyroid carcinoma; papillary thyroid carcinoma; follicular carcinoma; medullary thyroid carcinoma; familial adenomatous polyposis; PTEN-hamartoma tumor syndrome; Cowden disease; multiple endocrine neoplasia (MEN)
Categories
Ask authors/readers for more resources
Thyroid carcinomas derived front follicular cells are the most common endocrine malignancies, and papillary thyroid carcinoma (PTC) is the most common type. Although, the majority of papillary and follicular thyroid carcinomas (FTCs) are sporadic, familial forms have been described in recent years. Familial syndromes are classified into familial medullary thyroid carcinoma and familial nonmedullary thyroid carcinoma. Multifocal papillary carcinoma is the most frequent presentation of familial nonmedullary thyroid carcinoma, and based oil clinico-pathologic findings it is divided into 2 groups. The first includes familial syndromes characterized by a predominance of nonthyroidal tumors, such as familial adenomatous polyposis, PTEN-hamartoma tumor syndrome, Carney complex type 1, and Werner syndrome. The second group includes familial syndromes characterized by a predominance of NMTC. Such as pure familial (1) PTC with or without oxyphilia, IPTC with papillary renal cell carcinoma, and fPTC with multinodular goiter. Medullary thyroid carcinoma is derived from calcitonin-producing C cells. The familial form accounts for 20% to 25% of cases, and is usually a component of multiple endocrine neoplasia (MEN) IIA or IIB, or presents as pure familial medullary thyroid carcinoma syndrome. C-cell hyperplasia is the precursor lesion of these heritable syndromes. Some characteristic morphologic findings should alert the pathologist of a possible familial cancer syndrome, which may lead to further molecular genetic evaluation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available