Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 6, Pages 1060-1065Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201701532
Keywords
asymmetric catalysis; radical reaction; Cu-catalysis; DABSO; lactones
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Funding
- National Natural Science Foundation of China [21772085]
- Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics
- Shenzhen Virtual University Park
- Changzhou Jin-Feng-Huang program
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In the present work, an asymmetric copper-catalyzed radical multi-component cascade reaction of an unsaturated carboxylic acid, aryldiazonium tetrafluoroborate, and DABCO(SO2)(2) (DABSO) has been developed for the enantioselective synthesis of sulfonyl lactones. In this reaction, this SO2 surrogate, DABSO was applied for the first time in the construction of chiral compounds. This multiple-step asymmetric radical reaction was carried out under mild conditions and tolerated a wide range of substrates, resulting in the corresponding sulfonyl lactones with up to 95% chemical yields and 88% ee. The current reaction enriches the research contents of DABSO, and provides a new and efficient strategy to chiral functionalized lactones bearing quarternary stereogenic center.
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