Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 15, Pages 2879-2884Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800478
Keywords
difluoromethylene; cyanation; 3,3 '-spirocyclic indoline; dearomatization; quaternary carbon stereocenters
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Funding
- National Natural Science Foundation of China [21732002, 21672117, 21602117]
- Tianjin Natural Science Foundation [16JCZDJC32400]
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A protocol for visible-light-induced radical dearomatization/cyanation cascade reaction of indole derivatives is reported. This protocol provides straightforward access to gem-difluorinated and cyanated 3,3'-spirocyclic indolines with moderate to excellent diastereoselectivity and permits the construction of two contiguous sterically congested quaternary carbon stereocenters.
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