Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 4, Pages 808-813Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201701329
Keywords
C-C bond construction; cyclization; base-promoted; benzonitrile
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Funding
- National Basic Research Program of China (973) [2015CB856603]
- Chinese Academy of Sciences [XDB20000000]
- National Natural Science Foundation of China [20472096, 21372241, 21572052, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, 21772037, 21772226]
- Fundamental Research Funds for the Central Universities [222201717003]
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A facile synthesis of benzonitriles via a base-promoted tandem cyclization reaction of ,alpha,beta-unsaturated enones having electron-withdrawing group (EWG) and 2-acyl-acrylonitriles was developed. This new synthetic method to access benzonitriles is suitable for a wide range of substrates. A plausible reaction mechanism is proposed on the basis of previous literature and our own investigations.
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