Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 19, Pages 3781-3787Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800622
Keywords
Benzo[a]carbazole; Indolo[2; 1-a]isoquinoline; C-H Functionalization; 2-Arylindole; Sulfoxonium Ylide
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Funding
- National Natural Science Foundation of China (NSFC) [21572047]
- Program for Innovative Research Team in Science and Technology in Universities of Henan Province [15IRTSTHN003]
- Program for Science and Technology Innovation Talents in Universities of Henan Province [15HASTIT005]
- Plan for Scientific Innovation Talents of Henan Province [184200510012]
- 111 Project [D17007]
- Henan Center for Outstanding Overseas Scientists [GZS2018003]
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A highly chem- and regioselective synthesis of diversely substituted benzo[a]carbazoles and indolo[2,1-a]-isoquinolines through Rh(III)-catalyzed cascade reactions of 2-arylindoles with sulfoxonium ylides is presented. To be specific, treatment of 2-arylindoles, 2-arylindole-3-carbaldehydes, 2-arylindole-3-carbonitriles or 2-aryl-3-methylindoles with sulfoxonium ylides under the catalysis of Rh(III) led to the selective formation of 6-aryl/alkyl benzo[a]carbazoles, 5-acylbenzo[a]carbazoles, 6-amino-5-acylbenzo[a]carbazoles or 12-methylindolo[2,1-a]isoquinolines, respectively. Mechanistically, the formation of the title compounds involves a cascade process including metalation of the inert C(sp(2))-H bond, migratory insertion of ylide into the carbon-metal bond via an insitu carbenoid formation, protodemetalation, and condensation. To our knowledge, this is the first example in which -carbonyl sulfoxonium ylides were used as stable carbene precursors and bifunctional C2 synthons to afford benzo[a]carbazoles and indolo[2,1-a]isoquinolines.
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