Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 16, Pages 3164-3170Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800513
Keywords
Asymmetric catalysis; Mannich addition; Organocatalysis; Bisoxindoles; Squaramides
Categories
Funding
- National Natural Science Foundation of China [21272024]
Ask authors/readers for more resources
A squaramide-catalyzed asymmetric Mannich reaction of 3-fluorooxindoles to isatin-derived imines for synthesis of fluorinated 3,3-bisoxindoles with two contiguous stereocenters under mild conditions was developed. The corresponding 3,3-bisoxindoles were obtained in excellent yields with excellent diastereo- and enantioselectivities (up to 99% yield, >99:1dr and >99% ee). What's more, this reaction can be gram-scaled without compromising yield and stereoselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available