Journal
PHARMACEUTICALS
Volume 3, Issue 2, Pages 379-392Publisher
MDPI
DOI: 10.3390/ph3020379
Keywords
CPPs; neuroprotection; protein; protein interaction; drug discovery; brain
Categories
Funding
- Marie Curie Industry-Academia Partnerships and Pathways (IAPP) cPADS
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The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.
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