Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 14-15, Pages 3231-3236Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400218
Keywords
asymmetric catalysis; copper; decarboxylative propargylic alkylation; beta-keto acids; propargylic esters
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Funding
- Dalian Institute of Chemical Physics (CAS)
- National Key Technologies R&D Program of China [2012BAK25B03]
- Program for Liaoning Excellent Talents in University [LJQ 2013059]
- Science and Technology Fund of Dalian City [2011J21DW010]
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The first copper-catalyzed intermolecular enantioselective decarboxylative propargylic alkylation of propargylic esters with beta-keto acids as surrogates of ketones has been successfully developed by using a ketimine P, N, N-ligand. High yields and excellent enantioselectivities (up to 98% ee) have been achieved under the mild reaction conditions.
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