Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 16, Pages 3451-3455Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400328
Keywords
amines; Bronsted acids; catalysis; iron; reductive amination
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Funding
- State of Mecklenburg-Western Pomerania
- BMBF
- National Science Foundation of China [21372091]
- Research Fund for Doctoral Program of Higher Education of China [20130144120003]
- Science and Technology Department of Hubei Provence, China [2012FFB03002]
- Central China Normal University
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The direct asymmetric reductive amination (DARA) of ketones with anilines is described by combining a chiral Bronsted acid (TRIP) and the non-chiral Knolker iron complex as the catalyst system. In situ-formed imines are reduced with molecular hydrogen to give chiral amines in high yields (90%) and enantioselectivities of up to 99% ee.
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