Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 9, Pages 2097-2102Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400076
Keywords
allyl carbonates; allylation; C-H activation; enones; ketene dithioacetals; palladium
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Funding
- National Natural Science Foundation of China [21272232]
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The palladium-catalyzed oxidative Heck-type allylation of beta,beta-disubstitutedenones, i.e., alpha-oxoketene dithioacetals, was efficiently realized with allyl carbonates, providing a concise route to highly functionalized dienes. The present synthetic methodology utilizes the substrate activation strategy to activate the C-H bond of beta,beta-disubstituted enones by introduction of a 1,2-dithiolane functionality to make the enone substrate highly polarized and thus increase its reactivity, demonstrating rare examples for transition metal-catalyzed allylic substitution of beta,beta-disubstituted enones through a Heck-type allylation process.
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