Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 16, Pages 3341-3346Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400660
Keywords
C-H bond activation; domino reactions; 2-isocyanobiphenyls; methylation; phenanthridines
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Funding
- National Natural Science Foundation of China [21272028, 21202013]
- Innovation & Entrepreneurship Talents Introduction Plan of Jiangsu Province
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology
- State Key Laboratory of Coordination Chemistry of Nanjing University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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The di-tert butyl peroxide (DTBP)-promoted sequential reaction of isonitriles is developed, leading to 6-methylphenanthridine derivatives in moderate to excellent yields. DTBP served as both promoter and methyl source. The procedure proceeds through the addition of a methyl radical derived from the peroxide to the isonitrile followed by aromatic homolytic cyclization. It tolerates a series of functional groups, such as fluoro, chloro, acetyl, methoxycarbonyl, cyano and trifluoromethyl.
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