Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 2-3, Pages 475-484Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300717
Keywords
amides; amines; catalysis; niobium oxide; transamidation
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Funding
- GlaxoSmithKline (GSK)
- Singapore Economic Development Board (EDB) under GSK-Singapore Partnership for Green and Sustainable Manufacture
- Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore
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Mesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent-free conditions and is applicable to a wide range of primary amides and amines to provide N-alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug-like compounds.
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