4.7 Article

Direct Synthesis of Pyrrolo[3,4-c]quinolines from the Domino Reaction of Tosylmethyl Isocyanides and Aminochalcones

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 14-15, Pages 2974-2978

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400468

Keywords

bicyclization; chalcones; domino reactions; pyrrolo[3,4-c]quinolones; tosylmethyl isocyanide

Funding

  1. NNSFC [21172030, 21272034, 21202015]
  2. Young Scientific Research Foundation of Jilin Province [20140520083JH]
  3. Fundamental Research Funds for the Central Universities [12QNJJ010]

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A tandem formal [3+2] cycloaddition/cyclization reaction of aminochalcones with tosylmethyl isocyanide derivatives was developed for the practical and convenient synthesis of diverse tricyclic pyrrolo[3,4-c]quinolines in high to excellent yields. In this domino process, three new bonds and two rings are successively formed at ambient conditions.

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