Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 14-15, Pages 2974-2978Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400468
Keywords
bicyclization; chalcones; domino reactions; pyrrolo[3,4-c]quinolones; tosylmethyl isocyanide
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Funding
- NNSFC [21172030, 21272034, 21202015]
- Young Scientific Research Foundation of Jilin Province [20140520083JH]
- Fundamental Research Funds for the Central Universities [12QNJJ010]
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A tandem formal [3+2] cycloaddition/cyclization reaction of aminochalcones with tosylmethyl isocyanide derivatives was developed for the practical and convenient synthesis of diverse tricyclic pyrrolo[3,4-c]quinolines in high to excellent yields. In this domino process, three new bonds and two rings are successively formed at ambient conditions.
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