Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 1, Pages 153-159Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300728
Keywords
arylation; copper-catalyzed reaction; ortho-iodoacetophenones; methyl ketones; 1-naphthols
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Funding
- National Natural Science Foundation of China [21102080, 21372138]
- Tsinghua University Initiative Scientific Research Program [2011Z02150]
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A concise synthesis of 1-naphthols via cyclization of o-iodoacetophenones and methyl ketones has been realized under very mild conditions. The cyclization process is initiated by a rare copper-catalyzed arylation of simple methyl ketones with ortho-iodoacetophenones.
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