Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 11-12, Pages 2575-2579Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400043
Keywords
ambient temperature reaction; copper/N,N,N ',N '-tetramethylethylenediamine (Cu/TMEDA); C-S cross-coupling; N-substituted benzoheterocycles; water
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Funding
- National Natural Science Foundation of China [20972002, 21272006]
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Copper/N, N, N', N'-tetramethylethylenediamine (Cu/TMEDA)-catalyzed ambient temperature tandem reactions of isothiocyanates with 2-iodophenols or 2-iodoanilines in water without the protection of an inert atmosphere are described, which provide a simple, rapid, environmental method for the synthesis of a variety of 2-iminobenzo-1, 3-oxathioles and 2-aminobenzothiazoles in good yields. More important, the present reaction process needs only low amounts of copper catalyst (< 1 mol%) and can yield the products on a gram scale.
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