Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 2-3, Pages 523-529Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400735
Keywords
enantioselective; imine; mannich reaction; organocatalysis; thioester
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Funding
- Welch Foundation [AX-1573]
- National Institute on Minority Health and Health Disparities from the National Institutes of Health [G12 MD007591]
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A highly stereoselective Mannich reaction of S-phenyl thioesters was achieved by using bifunctional thiourea catalysts. Using a quinine-derived C6'-urea catalyst, the direct Mannich products of N-tosyl imines and S-phenyl thioesters were obtained in high yields and excellent diastereo- and enantioselectivities.
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