A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives

An efficient domino benzannulation strategy with the participation of sulfur ylides for the construction of biaryl compounds is disclosed. It could also be extended to the synthesis of alkenylated and alkynylated benzene derivatives under mild conditions. This versatile strategy combined with traditional metal-catalyzed cross-coupling methods should offer a practical route to construct complex multiaryl compounds.