Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 16, Pages 3095-3118Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300798
Keywords
aldol reaction; asymmetric catalysis; green chemistry; Lewis acids; water
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Funding
- Japan Society for the Promotion of Science (JSPS), Global COE Program
- University of Tokyo, MEXT, Japan, Japan Science Technology Agency (JST)
- Grants-in-Aid for Scientific Research [21225002, 13J10509] Funding Source: KAKEN
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Mukaiyama aldol reactions in aqueous media have been surveyed. While the original Mukaiyama aldol reactions entailed stoichiometric use of Lewis acids in organic solvents under strictly anhydrous conditions, Mukaiyama aldol reactions in aqueous media are not only suitable for green sustainable chemistry but are found to produce singular phenomena. These findings led to the discovery of a series of water-compatible Lewis acids such as lanthanide triflates in 1991. Our understanding on these beneficial effects in the presence of water will be deepened through the brilliant examples collected in this review.
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