Recent Advances in Catalytic Asymmetric Decarboxylative Addition Reactions

This review examines recent advances in asymmetric catalytic decarboxylative addition reactions which have become a powerful method to form CC and CX bond using relatively cheap and stable carboxylic compounds. In these reactions, new CC or CX bonds are formed with extrusion of carbon dioxide (CO2). Asymmetric decarboxylative addition reactions have become alternatives to traditional addition reactions. Various asymmetric reactions between carboxylic acids and unsaturated compounds are summarized. The challenges and opportunities of these reactions are discussed.