Atom-Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst

A novel chiral metal-organic framework (MOF) organocatalyst has been developed, based on readily available MIL-101 and the chiral primary diamine (1R,2R)-1,2-diphenylethylenediamine, by the post-synthetic modification. Over the developed chiral heterogeneous catalyst the asymmetric synthesis of (S)-warfarin with high enantioselectivity can be fulfilled on a gram-scale (2.8g) with excellent yield (92%) at low cost, making the synthesis method an ideal alternative to existing methods.