Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 6, Pages 1071-1076Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201201120
Keywords
alkynylation; asymmetric catalysis; N; O ligands; nucleophilic addition; oxygen heterocycles
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Funding
- Ministerio de Economia y Competitividad (Gobierno de Espana)
- FEDER (European Union) [CTQ2009-13083]
- Generalitat Valenciana [ACOMP2012-212, ISIC2012/001]
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A new enantioselective catalyst for the conjugate addition of terminal alkynes has been developed. Terminal alkynes react with 3-alkoxycarbonylcoumarins in the presence of diethylzinc and bis(hydroxyamide) ligands to give chiral non-racemic dihydrocoumarins substituted with an alkynyl group on the C-4 position with good yields and enantiomeric excesses up to 95%.
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