Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 2-3, Pages 327-331Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200845
Keywords
asymmetric catalysis; bifunctional organocatalysts; enantioselectivity; N,S-acetals; trifluoromethyl group
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Funding
- 973 Program [2011CB808600]
- National Natural Science Foundation of China [20972117, 21172176]
- Fundamental Research Funds for the Central Universities
- Large-scale Instrument And Equipment Sharing Foundation of Wuhan University
- [NCET-10-0649]
- [IRT1030]
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The first organocatalytic asymmetric addition of thiols to trifluoromethylaldimine for the construction of chiral trifluoromethylated N,S-acetals has been achieved in high yields (up to 99%) and excellent enantioselectivities (up to 95% ee) with 1mol% of a bifunctional organocatalyst.
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