Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 10, Pages 1917-1923Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300249
Keywords
asymmetric catalysis; epoxidation; hydrogen peroxide; phase-transfer catalysts; trifluoromethyl group
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Funding
- NSFC [21172018]
- Beijing Institute of Technology
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An efficient catalytic asymmetric epoxidation of -trifluoromethyl-,-disubstituted unsaturated ketones has been achieved by a pentafluorine-substituted phase-transfer catalyst with hydrogen peroxide (30%). dr) and excellent enantioselectivities (up to 99.7% ee). Low catalyst loading, recycle of catalyst, environmentally benign oxidant and easy transformation of the epoxides into medicinally important trifluoromethylated intermediate make our protocol much more practical.
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