Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 16, Pages 2971-2976Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200887
Keywords
asymmetric alpha-amination; continuous flow operation; diphenylprolinol silyl ethers; organocatalysis; supported catalysts
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Funding
- Institute of Chemical Research of Catalonia (ICIQ) Foundation
- MINECO [CTQ2008-00947/BQU, CTQ2012-38594-C02-01]
- DIUE [2009SGR623]
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Polystyrene (PS)-supported diphenylprolinol silyl ethers have been developed as highly active catalysts for the enantioselective a-amination of aldehydes. Understanding the mechanism of catalyst deactivation has led to the development of reaction conditions notably extending catalyst life in repeated recycling (10 cycles; accumulated TON of 480) and has allowed the implementation of a continuous flow alpha-amination process (6 min residence time, 8 h operation).
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