Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 14-15, Pages 2854-2858Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200589
Keywords
asymmetric catalysis; copper; primary amines; propargylic amination; secondary amines
Categories
Funding
- Dalian Institute of Chemical Physics (CAS)
Ask authors/readers for more resources
Chiral tridentate P,N,N ligands have been demonstrated to be highly efficient for the copper-catalyzed enantioselective propargylic amination of propargylic acetates with both primary and secondary amines as nucleophiles, affording the corresponding propargylic amines in high yields and with excellent enantioselectivities (up to 97% ee for secondary amines, and up to 96% ee for primary amines). Furthermore, the present catalytic system was also effective for the more challenging aliphatic propargylic acetate substrates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available