Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 8, Pages 1417-1421Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100967
Keywords
azides; homogeneous catalysis; phosphorus heterocycles; Staudinger reduction; synthetic methods
Categories
Funding
- Netherlands Ministry of Economic Affairs
- Netherlands Ministry of Education, Culture and Science
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The first Staudinger reduction that is catalytic in phosphine has been developed, showing excellent yields and functional group selectivity. To this end we utilised dibenzophosphole catalysts and mild in situ reduction of the intermediate iminophosphoranes. We could avoid the necessity of water during the reduction, obtained no phosphine oxides as waste and thus enabled facile purification of the product. A range of azides was converted into amines with good to excellent yields and high functional group tolerance.
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