4.7 Article

Copper-Catalyzed Ultrasound-Expedited N-Arylation of Sulfoximines using Diaryliodonium Salts

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 6, Pages 986-990

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100808

Keywords

N-arylation; C-N cross-coupling; iodonium salts; PEG-400; polyethylene glycol 400; sulfoximines

Funding

  1. U.S. Department of Energy
  2. EPA

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An ultrasound-accelerated route for an expeditious N-arylation of NH-sulfoximines is described that involves the use of diaryliodonium salts in aqueous polyethylene glycol-400 and copper(I) bromide as catalyst at room temperature. The high yields of the products and simple work-up are the highlights of the protocol.

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