Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 11-12, Pages 2135-2140Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200195
Keywords
C-H activation; olefin coupling partners; olefination; palladium; pyridines
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Funding
- State Key Laboratory of Applied Organic Chemistry
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A novel and efficient protocol for the C-2 selective olefination of pyridines via a palladium-catalyzed oxidative cross-coupling reaction has been developed. A wide range of pyridines and olefin substrates including acrylic ester, styrene, and acrylamide are compatible. The products are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.
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