Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 6, Pages 964-968Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100833
Keywords
alkanes; C?H activation; compound I; enzyme catalysis; metalloenzymes; methane oxidation
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Funding
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Science, U.S. Department of Energy [DE-FG02-06ER15762]
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Terminal oxidant-supported P450 reactions alleviate the need for substrate binding to initiate catalysis by chemically generating compound I. This allows investigation of the innate substrate range of the enzyme active site. Using iodosylbenzene as the oxidant, CYP153A6, a medium-chain terminal alkane hydroxylase, exhibits methanol formation in the presence of methane demonstrating that P450-mediated methane hydroxylation is possible.
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