Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 354, Issue 9, Pages 1805-1812Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200073
Keywords
asymmetric catalysis; homogeneous catalysis; hydrogenation; iridium; microreactors; rhodium
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Funding
- EPSRC [EP/F069685/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
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In this update, the asymmetric homogeneous hydrogenation of a number of trisubstituted olefins utilizing the recently developed tube-in-tube gas-liquid flow reactor is described. A number of chiral iridium- and rhodium-based catalysts and other parameters such as pressure, solvent, temperature and catalyst loading were screened. The advantage of the flow set-up for rapid screening and optimization of reaction parameters is illustrated. Furthermore, a comparative study using batch conditions aided in the optimization of the flow reaction set-up. The set-up was further modified to recycle the catalyst which prolonged catalytic activity.
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