Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 5, Pages 781-787Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000807
Keywords
aryl halides; C-C coupling; cyanation; formamide; nitriles; palladium
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Funding
- University Grant Commission, India under Green Technology Centre of Institute of Chemical Technology
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A novel method for cyanation of aryl halides using formamide as a non-toxic cyanide source is reported. It is a single-step, solvent-free method wherein formamide itself acts as solvent as well as source of cyanide in the presence of phosphorus oxychloride and palladium acetate/xantphos catalyst. Aryl iodides as well as aryl bromides provided moderate to excellent yields of up to 93%.
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