Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 16, Pages 2976-2980Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100410
Keywords
aldol reaction; decarboxylative addition; enantioselectivity; organic catalysis
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Funding
- JSPS [20750074]
- Toyoaki Foundation
- Grants-in-Aid for Scientific Research [22750089, 11J06270, 20750074] Funding Source: KAKEN
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The organocatalytic enantioselective decarboxylative addition of malonic acids half thioesters to isatins using a squaramide catalyst afforded the products with high enantioselectivity. These products are key intermediates in the synthesis of 3-substituted 3-hydroxy-2-oxindole derivatives. The first enantioselective synthesis of (-)-flustraminol B has been accomplished.
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