4.7 Article

Grignard-Type Arylation of Aldehydes via a Rhodium-Catalyzed C-H Activation under Mild Conditions

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 8, Pages 1269-1273

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100232

Keywords

aldehydes; arylation; C-H activation; Grignard-type reaction; rhodium catalysis

Funding

  1. Canada Research Chair Foundation
  2. CFI
  3. NSERC

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An efficient Grignard-type arylation of aldehydes via aryl C-H activation was achieved under mild conditions catalyzed by rhodium. The reaction provides an easy access to a wide variety of benzyl alcohols and can tolerate various functional groups as well as air and water.

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