4.7 Article

Synthesis of Arylated Quinolines by Chemo- and Site-selective Suzuki-Miyaura Reactions of 5,7-Dibromo-8-(trifluoromethanesulfonyloxy)quinoline

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 14-15, Pages 2761-2774

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100165

Keywords

catalysis; palladium; quinolines; regioselectivity; Suzuki-Miyaura reaction

Funding

  1. DAAD

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Arylated quinolines were prepared by Suzuki-Miyaura reactions of 5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline. The reactions proceed with excellent site-selectivity. The first, second and third attack occur at positions 5, 7 and 8, respectively.

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